首页|University of Toronto Reports Findings in Robotics (Robotic microinjection enabl es large-scale transgenic studies of Caenorhabditis elegans)
University of Toronto Reports Findings in Robotics (Robotic microinjection enabl es large-scale transgenic studies of Caenorhabditis elegans)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Robotics is the subjec t of a report. According to news reporting originating in Toronto, Canada, by Ne wsRx journalists, research stated, "The nematode Caenorhabditis elegans is widely employed as a model organism to study basic biological mechanisms. Ho wever, transgenic C. elegans are generated by manual injection, which remains lo w-throughput and labor-intensive, limiting the scope of approaches benefitting f rom large-scale transgenesis. Here, we report a robotic microinjection system, i ntegrating a microfluidic device capable of reliable worm immobilization, transf er, and rotation, for high-speed injection of C. elegans." The news reporters obtained a quote from the research from the University of Tor onto, "The robotic system provides an injection speed 2-3 times faster than that of experts with 7-22 years of experience while maintaining comparable injection quality and only limited trials needed by users to become proficient. We furthe r employ our system in a large-scale reverse genetic screen using multiplexed al ternative splicing reporters, and find that the TDP-1 RNA-binding protein regula tes alternative splicing of zoo-1 mRNA, which encodes variants of the zonula occ ludens tight junction proteins."
TorontoCanadaNorth and Central Ameri caCaenorhabditis elegansEmerging TechnologiesGeneticsLife Science Resear chMachine LearningRhabditidaRhabditidaeRoboticsRobots
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