首页|China National Center for Bioinformation Reports Findings in Genomics Proteomics and Bioinformatics (Identify Non-mutational p53 Functional Deficiency in Human Cancers)
China National Center for Bioinformation Reports Findings in Genomics Proteomics and Bioinformatics (Identify Non-mutational p53 Functional Deficiency in Human Cancers)
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New research on Biotechnology - Genomi cs Proteomics and Bioinformatics is the subject of a report. According to news r eporting originating from Beijing, People's Republic of China, by NewsRx corresp ondents, research stated, "An accurate assessment of p53's functional status is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with nonmutational p53 inactivations that are not detecta ble through DNA sequencing." Our news editors obtained a quote from the research from China National Center f or Bioinformation, "These undetected cases are often misclassified as p53-normal , leading to inaccurate prognosis and downstream association analyses. To addres s this issue, we built the support vector machine (SVM) models to systematically reassess p53's functional status in TP53 wild-type (TP53 WT) tumors from multip le The Cancer Genome Atlas (TCGA) cohorts. Cross-validation demonstrated the goo d performance of the SVM models with a mean area under curve (AUC) of 0.9822, pr ecision of 0.9747, and recall of 0.9784. Our study revealed that a significant p roportion (87%-99%) of TP53 WT tumors actually have co mpromised p53 function. Additional analyses uncovered that these genetically int act but functionally impaired (termed as predictively reduced function of p53 or TP53 WT-pRF) tumors exhibited genomic and pathophysiologic features akin to TP5 3 mutant tumors: heightened genomic instability and elevated levels of hypoxia."
BeijingPeople's Republic of ChinaAsi aBiotechnologyCancerGeneticsGenomics Proteomics and BioinformaticsHeal th and MedicineOncologyp53 Gene
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