Changes in faecal microbiota in 6- to 12-year-old children after a new nutritional strategy: the ALINFA randomised controlled trial
一项新的营养策略后6-12岁儿童粪便菌群的变化:ALINFA随机对照试验
Naroa Andueza 1Jose I. Riezu-Boj 2Inigo Clemente-Larramendi 1Marta Cuervo 2Santiago Navas-Carretero3
作者信息
- 1. Faculty of Pharmacy and Nutrition, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain||Center for Nutrition Research, University of Navarra, Pamplona 31008, Spain
- 2. Faculty of Pharmacy and Nutrition, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain||Center for Nutrition Research, University of Navarra, Pamplona 31008, Spain||Navarra Institute for Health Research (IdiSNA), Pamplona 31008, Spain
- 3. Faculty of Pharmacy and Nutrition, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain||Center for Nutrition Research, University of Navarra, Pamplona 31008, Spain||Navarra Institute for Health Research (IdiSNA), Pamplona 31008, Spain||Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBERObn), Institute of Health Carlos Ⅲ, Madrid 28029, Spain
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摘要
肠道菌群似乎在健康和疾病中发挥着关键作用。本研究旨在评估6-12岁儿童营养干预对菌群的影响，并确定可能参与变化的饮食成分。进行了一项为期2个月的平行对照随机试验。营养干预是根据地中海饮食的建议对两个干预组进行的，不同之处在于ALINFA组在完全饮食的基础上进行了更密集的干预，而对照组则提供了饮食建议。干预后，ALINFA组的微生物群落丰度和多样性增加，不同细菌足跟丰度变化。这些变化主要受纤维摄入量和脂肪消耗类型的影响。ALINFA营养干预似乎能够积极影响儿童的菌群，在2个月内显示出明显的变化。
Abstract
Gut microbiota seems to play a critical role in health and disease. This study aimed to evaluate the effect of a nutritional intervention in children 6-12 years old on the microbiota and to identify possible dietary components involved in the change. A 2-month parallel, controlled randomised trial was conducted. The nutritional intervention was based on the recommendations of the Mediterranean diet, for both intervention groups, with the difference that in the ALINFA group a more intensive intervention based on a complete diet, while in the control group, dietary advice was provided. After the intervention, ALINFA group showed an increase in the richness and diversity of their microbiota as well as changes in the abundance of different bacterial heels. These changes were mainly influences by fibre intake and the type of fat consumed. The ALINFA nutritional intervention seems to be able to positively influence children's microbiota, showing significant changes within 2 months.
Key words
Children, fat intake, fibre intake, microbial richness, microbiota, nutritional intervention引用本文复制引用
出版年
2024
NETL
NSTL
Wiley