Robotics & Machine Learning Daily News2024,Issue(Dec.4) :17-17.

Italian Institute of Technology Reports Findings in Machine Learning (Investigat ing Ligand-Mediated Conformational Dynamics of PremiR21: A Machine-Learning-Aid ed Enhanced Sampling Study)

意大利理工学院报告了机器学习的发现(研究PremiR21配体介导的构象动力学:机器学习辅助ed增强抽样研究)

Robotics & Machine Learning Daily News2024,Issue(Dec.4) :17-17.

Italian Institute of Technology Reports Findings in Machine Learning (Investigat ing Ligand-Mediated Conformational Dynamics of PremiR21: A Machine-Learning-Aid ed Enhanced Sampling Study)

意大利理工学院报告了机器学习的发现(研究PremiR21配体介导的构象动力学:机器学习辅助ed增强抽样研究)

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摘要

由一名新闻记者-机器人与机器学习日报的工作人员新闻编辑每日新闻-机器学习的新研究是一篇报道的主题。根据新闻报道来自意大利热诺瓦的NewsRx记者的研究表明:“微小RNA(miRNA)是短的、非编码的。”RNA链S通过影响蛋白质转移的抑制来调节mRNA的活性,以及它们的失调与几种病理有关。特别是MI21与肿瘤发生与抗癌药物抵抗,使其成为药物设计的重要靶点。miR21生物发生涉及一些生化途径,包括其前体pre-miR21被酶切割骰子本文对pre-miR21的构象动力学进行了研究,重点研究了pre-miR21的构象动力学adenine29在Dicer-Bindin G倾向和非活动状态之间切换。

Abstract

By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News – New research on Machine Learning is th e subject of a report. According to news reportingfrom Genova, Italy, by NewsRx journalists, research stated, “MicroRNAs (miRs) are short, noncodingRNA strand s that regulate the activity of mRNAs by affecting the repression of protein tra nslation, andtheir dysregulation has been implicated in several pathologies. mi R21 in particular has been implicated intumorigenesis and anticancer drug resis tance, making it a critical target for drug design. miR21 biogenesisinvolves pr ecise biochemical pathways, including the cleavage of its precursor, pre-miR21, by the enzymeDicer. The present work investigates the conformational dynamics o f pre-miR21, focusing on the role ofadenine29 in switching between Dicer-bindin g-prone and inactive states.”

Key words

Genova/Italy/Europe/Cyborgs/Drugs an d Therapies/Emerging Technologies/Machine Learning

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出版年

2024
Robotics & Machine Learning Daily News

Robotics & Machine Learning Daily News

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