首页|Strain-level multidrug-resistant pathogenic bacteria in urban wastewater treatment plants: Transmission, source tracking and evolution

Strain-level multidrug-resistant pathogenic bacteria in urban wastewater treatment plants: Transmission, source tracking and evolution

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  • NETL
  • NSTL
  • Elsevier
© 2024 Elsevier LtdWastewater treatment plants (WWTPs) serve as reservoirs for various pathogens and play a pivotal role in safeguarding environmental safety and public health by mitigating pathogen release. Pathogenic bacteria, known for their potential to cause fatal infections, present a significant and emerging threat to global health and remain poorly understood regarding their origins and transmission in the environment. Using metagenomic approaches, we identified a total of 299 pathogens from three full-scale WWTPs. We comprehensively elucidated the occurrence, dissemination, and source tracking of the pathogens across the WWTPs, addressing deficiencies in traditional detection strategies. While indicator pathogens in current wastewater treatment systems such as Escherichia coli are effectively removed, specific drug-resistant pathogens, including Pseudomonas aeruginosa, Pseudomonas putida, and Aeromonas caviae, persist throughout the treatment process, challenging complete eradication efforts. The anoxic section plays a predominant role in controlling abundance but significantly contributes to downstream pathogen diversity. Additionally, evolution throughout the treatment process enhances pathogen diversity, except for upstream transmission, such as A. caviae str. WP8-S18-ESBL-04 and P. aeruginosa PAO1. Our findings highlight the necessity of expanding current biomonitoring indicators for wastewater treatment to optimize treatment strategies and mitigate the potential health risks posed by emerging pathogens. By addressing these research priorities, we can effectively mitigate risks and safeguard environmental safety and public health.

Drug-resistant pathogensMetagenomicssource trackingStrain-level evolutionWastewater treatment plants

Zhao Y.、Gao S.-H.、Dai Z.、Li Q.、Liang B.、Wang A.、Huang F.、Gao R.、Fan L.、Lei Z.、Wang W.

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State Key Laboratory of Urban Water Resource and Environment School of Civil & Environmental Engineering Harbin Institute of Technology Shenzhen

State Key Laboratory of Urban Water Resource and Environment School of Environment Harbin Institute of Technology

Department of Ocean Science and Engineering Southern University of Science and Technology (SUSTech)||Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

Department of Ocean Science and Engineering Southern University of Science and Technology (SUSTech)

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2024

10.1016/j.watres.2024.122538

Water research: A journal of the international water association

Water research: A journal of the international water association

EI
ISSN：0043-1354
年,卷(期)：2024.267(Dec.1)
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