首页|A Neuronal Signal Sorting and Amplifying Nanosensor for EEG-Concordant Imaging-Guided Precision Epilepsy Ablation

A Neuronal Signal Sorting and Amplifying Nanosensor for EEG-Concordant Imaging-Guided Precision Epilepsy Ablation

扫码查看
原文链接
  • NETL
  • NSTL
  • Wiley
Surgery remains an essential treatment for managing drug-resistantfocal epilepsy， but its accessibility and efficacy are limited in patients withoutdistinct structural abnormalities on magnetic resonance imaging (MRI)。Potassium ion (K~+)， a critical marker for seizure-associated neuronal signaling，shows significant promise for designing sensors targeting hidden epilepticfoci。 However， existing sensors cannot cross the blood-brain barrier and lackthe ability to specifically enrich and amplify K~+ signals in the brain with hightemporal and spatial resolution。 Here， an intravenously administered neuronalsignal sorting and amplifying nanosensor (NSAN) is reported that combinesreal-time dynamic reversible K+ fluorescence imaging with high-resolutionstructural MRI， enabling electroencephalogram-concordant imagingof MRI-negative epileptic foci。 Guided by NSANs， minimally invasive surgeryis successfully performed in both intrahippocampal kainic acid (KA) epilepsymodel with foci confined to the ipsilateral hippocampus， and intraperitonealKA model where foci are randomly distributed， resulting in sustainedseizure control and cognitive improvement。 These findings highlightthe NSAN as a transformative tool for visualizing hidden epileptic foci，thereby broadening eligibility for minimally invasive and precision surgicalintervention。

dual-mode imagingimaging-guided surgerynanosensorsneurological diseasepotassium ions

Qiyue Wang、Sirui Cui、Dao Shi、Pan Tao、Chencheng Zhang、Fang Wang、Peihua Lin、Fangyuan Li、Daishun Ling

展开 >

Department of Clinical LaboratorySongjiang Research InstituteShanghai Key Laboratory of Emotions and Affective Disorders (LEAD)Songjiang Hospital Affiliated to Shanghai Jiao Tong University School ofMedicineShanghai 201600, China||Frontiers ScienceCenter for Transformative MoleculesSchool of Chemistry and Chemical EngineeringSchool of Biomedical EngineeringNationalCenter for TranslationalMedicineState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong UniversityShanghai 200240, China

Institute of PharmaceuticsCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058, China

Frontiers ScienceCenter for Transformative MoleculesSchool of Chemistry and Chemical EngineeringSchool of Biomedical EngineeringNationalCenter for TranslationalMedicineState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong UniversityShanghai 200240, China

Department of NeurosurgeryClinical Neuroscience CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025, China

Clinical Research Center for Mental DisordersShanghai Pudong New Area Mental Health CenterSchool of MedicineTongji UniversityShanghai 200124, China

Department of Clinical LaboratorySongjiang Research InstituteShanghai Key Laboratory of Emotions and Affective Disorders (LEAD)Songjiang Hospital Affiliated to Shanghai Jiao Tong University School ofMedicineShanghai 201600, China||Institute of PharmaceuticsCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058, China

展开 >

2025

10.1002/adma.202408864

Advanced Materials

Advanced Materials

ISSN：0935-9648
年,卷(期)：2025.37(5)
  • 53