首页|Kanemite used as carrier of procainamide hydrochloride and sustained release of drugs
Kanemite used as carrier of procainamide hydrochloride and sustained release of drugs
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NETL
NSTL
Springer Nature
Abstract Kanemite used as carrier of procainamide hydrochloride (PA) has been investigated. X-ray diffraction (XRD) and infra-red spectra (IR) suggested that the cationic PA was incorporated into the kanemite. Compositional analyses by CHN elemental analyzer and scanning electron microscope equipped with energy dispersive spectra (SEM-EDS) revealed that the loading capacity of the kanemite-based composite for cationic PA was about 24.70%. Drug release characterized by UV-vis absorption spectra showed an initial quick release followed by a sustained release. The mean cumulative concentration of the PA released either in phosphate buffer solution (pH = 7.4) or in HCl solution (pH = 1.3) with time was fitted well with ExpDec3 model, namely equation C = A1exp(-t/τ1) + A2exp(-t/τ2) + A3exp(-t/τ3) + C0. Moreover, the drug release exhibited small standard deviation, indicating good repeatability. Nuclear Magnetic Resonance results indicated that the chemical shifts of the hydrogen signals within PA changed significantly after the PA was incorporated into the kanemite, implying strong interaction between the kanemite and PA. Based on these results, the mechanism of PA incorporated into kanemite was proposed.
Yufeng Chen、Yu Zhong、Yijun Liu、Fang Guo、Wanyun Feng、Xiaoqiang Shang、Yongxiu Li
NETL
NSTL
Springer Nature
