首页|Intracranial Disease-Region Composite-Interpretation Technology for Enhanced Source Localization in Pediatric Epilepsy Surgery

Intracranial Disease-Region Composite-Interpretation Technology for Enhanced Source Localization in Pediatric Epilepsy Surgery

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  • NETL
  • NSTL
  • IEEE
Electroencephalography (EEG) based source localization (ESL) is a useful method to localize the epileptogenic zone in epilepsy surgery. However, previous techniques only perform 3-dimensional (3D) reconstruction, and do not conduct delineation on the cortex surface as a resection guidance, and there is very little data on intracranial EEG and pediatric cases. This study proposes an Intracranial Disease-region Composite-interpretation (IDC) EEG-based source localization (ESL) scheme that uses 3D extended reality (XR) edge computing to enhance visualization and comprehensive interpretation of intracranial EEG-based source localization (iESL) for patients with pediatric epilepsy. The proposed IDC-ESL method was effective in predicting the surgical outcome in patients with focal epilepsy, which can be effectively used for epilepsy surgery. Seizure freedom was clearly associated with complete resection of combined EEG features of interictal spike, high-frequency oscillation (HFO), and seizure onset zone (SOZ), and it had the highest significance in localizing the epileptogenic zone. However, for patients with Lennox-Gastaut syndrome (LGS), IDC-ESL was not performed effectively because of a deeply seated lesion and multifocal abnormalities. It could only roughly estimate the affected area, mainly because of insular involvement. Cautious interpretation based on intraoperative electrocorticography (ECoG) is required for accurate insular resection, particularly for LGS cases.

ElectroencephalographyElectrodesEpilepsySurgeryLocation awarenessScalpMagnetic resonance imagingMonitoringThree-dimensional displaysHafnium oxide

Jeongyoon Shin、Wonsik Yang、Jungmin Seo、Won Seok Chang、Heung Dong Kim、Se Hee Kim、Jong-Moon Chung

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Yonsei Biomedical Research Institute, College of Medicine, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea|School of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea|Department of Emergency Medicine, College of Medicine, School of Electrical and Electronic Engineering, College of Engineering, and, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea

School of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea

Department of Neurosurgery, Brain Research Institute, College of Medicine, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea

Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University, Jongno-gu, Seoul, Republic of Korea

Department of Pediatrics, College of Medicine, Severance Children’s Hospital, Epilepsy Research Institute, Division of Pediatric Neurology, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea

Department of Emergency Medicine, College of Medicine, School of Electrical and Electronic Engineering, College of Engineering, and, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea

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2025

10.1109/TNSRE.2024.3514940

IEEE transactions on neural systems and rehabilitation engineering: a publication of the IEEE Engineering in Medicine and Biology Society

IEEE transactions on neural systems and rehabilitation engineering: a publication of the IEEE Engineering in Medicine and Biology Society

ISSN：
年,卷(期)：2025.33(1)
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