首页|Patent Application Titled 'Apparatus And Method For Control Of Cell Processing S ystem' Published Online (USPTO 20240399365)
Patent Application Titled 'Apparatus And Method For Control Of Cell Processing S ystem' Published Online (USPTO 20240399365)
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NETL
NSTL
Reporters obtained the following quote from the background information supplied by the inventors:“Cellular therapies based on hematopoietic stem cells (HSCs), chimeric antigen receptor (CAR) T cells,NK cells, tumor infiltrating lymphocyte s (TILs), T-cell receptors (TCRs), regulatory T cells (T regs),gamma delta (gd) T cells, and others rely on manufacturing of cell products. Manufacturing of su chcell products typically involves multiple cell processing steps. Conventional solutions for manufacture ofcell products rely on cumbersome manual operations performed in expensive biosafety cabinets and/orclean rooms. Skilled laborator y technicians, adequate sterile enclosures such as cleanroom facilities, andass ociated protocols and procedures for regulated (GMP) manufacturing are expensive . Many currentmanufacturing processes employ numerous manual reagent preparatio n and instrument manipulation stepsduring a manufacturing protocol, and the pro cesses may require several days or even weeks. Even platformsdescribed as autom ated cell processing in a closed system generally rely on pre-configured instrum entationand tubing sets that limit operational flexibility and do not reliably prevent process failure due to accidentaloperator/human error.
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