首页|Immunostimulatory effects of three traditional Okinawan vegetable extracts on activation of macrophage-like cells, and tumor growth suppression by Crepidiastrum lanceolatum Nakai in mice
Immunostimulatory effects of three traditional Okinawan vegetable extracts on activation of macrophage-like cells, and tumor growth suppression by Crepidiastrum lanceolatum Nakai in mice
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
Japanese Soc Food Sci & Technology
To clarify the effects of traditional Okinawan vegetable extracts on the activation of immunocompetent cells, we prepared methanol extracts from lyophilized powders of Crepidiastrum lanceolatum Nakai (hosoba-wadan), Peucedanum japonicum Thunb. (botan-bofu) and Artemisia indica Willd. var. orientalis (Pamp.) H. Hara (nishi-yomogi). We examined nitric oxide and cytokine production and phagocytosis of macrophage-like J774.1 cells following stimulation with extracts as activation indices. Moreover, we investigated the effect of the hosoba-wadan extract on tumor growth in tumor-bearing mice. IL-6 and TNF-a production and incorporation of microbeads in the 3 fig/mL hosoba-wadan extract group were significantly higher than in the other groups. We also observed that intraperitoneal administration (30 mg/mouse) of the hosoba-wadan extract significantly suppressed tumor growth compared with the saline group. Moreover, the hosoba-wadan extract resulted in significant increases of serum TNF-a and IFN-y concentrations in the mice. These results suggest that the hosoba-wadan extract activated immunocompetent cells and enhanced host immunity.
NETL
NSTL
Japanese Soc Food Sci & Technology
