Lead Mediated Lipopolysaccharides Exacerbates Fatty Liver Processes in High-Fat Diets-Induced Mice

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外文摘要：Obesity leads to a variety of health risks, and lead, which is ranked second in Agency for Toxic Substances and Disease Registry's priority list of harmful substances, may be more harmful to individuals that are obese. C57BL/6 mice were fed a normal diet or a high-fat diet with or without exposure to 1 g/L lead exposure in drinking water for 8 consecutive weeks. Serum and hepatic biochemistry analysis, histopathological observation, and RT-qPCR were used to explore the potential mechanism of liver damage in obese individuals after Pb exposure, and fecal microbiota transplantation was performed to investigate the role of the gut microbiota in the progression of fatty liver disease. We found that the progression of fatty liver disease induced by high-fat diets was accelerated by chronic lead intake. In addition, the occurrences of liver injury in recipient mice suggested the role of the gut microbiota. These findings indicated that the combination of lead and a HFD exacerbated hepatic lipotoxicity by activating LPS-mediated inflammation, and that gut microbiota disorders and impaired intestinal barrier function play pivotal roles in the progression of fatty liver disease.

外文关键词：

fecal microbiota transplantationgut-liver axisinflammationleadlipid metabolism

作者：

Penghui Nie、Liehai Hu、Tao You、Tiantian Jia、Hengyi Xu

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作者单位：

State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China

State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China||International Institute of Food Innovation co. Ltd., Nanchang University, Nanchang, People's Republic of China

出版年：

2025

DOI：

10.1002/tox.24463

Environmental toxicology

ISSN：1520-4081

年,卷(期)：2025.40(5/6)