首页|Prenatal exposure to manganese and objectively measured sleep disturbances in early childhood

Prenatal exposure to manganese and objectively measured sleep disturbances in early childhood

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Inadequate sleep in childhood can impact long-term neurodevelopmental outcomes; thus, identifying modifiable risk factors amenable to intervention is a priority. Development of sleep neuroarchitecture begins in utero. Manganese (Mn) is a trace element known to be both an essential element for optimal neurodevelopment and, at insufficient or excess levels, a neurotoxicant. We examined associations between prenatal urinary Mn levels and objectively measured sleep outcomes in children aged 6.7 ± 2.0 years and explored sex-specific effects. Sleep was assessed using multi-day actigraphy (n = 222) and single-night in-home polysomnography (PSG) (n = 102). Linear and non-linear associations between prenatal log-transformed Mn levels and sleep outcomes were examined using multivariable linear regression and generalized additive models, respectively. Non-linear associations were examined based on low, moderate (referent group) and high Mn levels indexed by tertiles. Sex-specific effects were evaluated using 2-way interaction terms. A doubling increase in Mn was associated with a 30.9 min (95 % CI = -52.0, -9.86) decrease of average sleep period duration and a 21.9 min (95 % CI = -39.9, -4.02) decrease of average sleep duration on actigraphy; associations were more pronounced in males. Compared to children born to mothers with moderate prenatal urinary Mn levels, children whose mothers had "low" Mn had a percent increase in minutes of wake after sleep onset (WASO) (p = 89.6; 95 % CI = 16.2, 206.5) and a decrease in sleep efficiency percentage (p = -6.47; 95 % CI = -11.3, -1.68) on PSG. Sleep problems may be influenced by environmental exposures, such as metals, and disruption can occur as early as pregnancy.

Prenatal manganeseChildhood sleepSex differencesNon-linear associations

Francheska M. Merced-Nieves、Elena Colicino、Brent Coull、Sonali Bose、Susan Redline、Robert O. Wright、Rosalind J. Wright

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Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA||Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA||Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA||Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Department of Medicine and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA||Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, USA

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2025

Environmental research

Environmental research

SCI
ISSN:0013-9351
年,卷(期):2025.279(Pt.1)
  • 59