首页|Association of long-term PM 2.5 and its components exposure with ovarian hyperstimulation syndrome risk in assisted reproductive technology patients
Association of long-term PM 2.5 and its components exposure with ovarian hyperstimulation syndrome risk in assisted reproductive technology patients
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NETL
NSTL
Elsevier
This study investigates the impact of long-term exposure to ambient fine particulate matter (PM2.5) and its components on the risk of ovarian hyper stimulation syndrome (OHSS) in women undergoing assisted reproductive technology (ART). We conducted a retrospective cohort study at a large reproductive medical center in Sichuan Province, China, including 45,703 women undergoing their first ART cycle between January 2018 and May 2024. The overall incidence of OHSS was 1.67 %. Exposure to PM2.5 and its components (black carbon [BC], organic matter [OM], sulfate [SO42-], nitrate [NO3-], and ammonium [NH4+]) was estimated based on residential addresses. Exposure windows were defined as three distinct time periods within the year preceding oocyte retrieval: (1) the 3 months immediately before retrieval, (2) months 4-12 before retrieval, and (3) the entire 12-month period before retrieval. Poisson regression assessed single-pollutant effects, while quantile g-computation evaluated joint effects. Distributed lag nonlinear models (DLNM) identified critical exposure windows. Results indicated that exposure to each pollutant was significantly associated with increased OHSS risk. Combined exposure over the previous year increased OHSS risk (RR: 1.22, 95 % CI: 1.13-1.32), with BC and NH4+ contributing most to 1 year effects, and SO42- dominating the 3 months before retrieval. DLNM identified the first 6 months before oocyte retrieval as a susceptible period, and stratified analysis showed that younger women (<35 years) were more sensitive to exposure. These findings underscore the need for policies to reduce air pollution and safeguard reproductive health.
NETL
NSTL
Elsevier
