Abstract
Fruit diseases caused by pathogen infections lead to huge economic losses annually.Microbial-derived bioactive substances have gained prominence in biological control because of their non-toxic,environmentally friendly,and non-resistant properties.This review highlights the novel contributions of recent advancements in microbial-derived bioactive substances for fruit disease management.Diverse microbial sources of these substances are systematically compiled and analyzed,methods for their separation and purification are introduced,and their mechanisms of action in inhibiting fruit pathogens are elucidated.Importantly,this review emphasizes their unique ability to simultaneously suppress pathogens and enhance host resistance,offering a dual-mode approach to disease control.Furthermore,their stability,safety,and compatibility are discussed,providing a robust foundation for future commercial applications.By integrating theoretical insights with practical guidance,this review aims to advance the under-standing and utilization of microbial-derived bioactive substances in fruit disease management.