Abstract
© The Author(s), under exclusive licence to Springer Nature B.V. 2025.Cheese manufacture yields large quantities of waste, and second cheese whey and cheese whey, in particular, present great environmental concerns by virtue of their very high organic load. In this review, upcycling strategies for cheese waste and associated by-products are investigated in a sustainable context, focusing on their main constituents: lactose, proteins, and minerals. Major processes such as lactose fermentation to ethanol identify opportunities for valorization. Whey protein-based edible coatings and films are innovative uses that aid in food packaging and preservation sustainability. In addition, the review addresses various industrial applications ranging from biofuel production, bioplastics, and food additives to medicinal applications such as nutraceuticals and bioactive compounds from cheese waste. This review highlights the upcycling value of cheese waste as a key action to achieve value addition and circular economy in the dairy industry.