首页|Three new eremophilane sesquiterpenes and one new related derivative from Nemania sp. HDF-Br-5, an endophytic fungus of the endangered conifer Pseudotsuga gaussenii Flous

Three new eremophilane sesquiterpenes and one new related derivative from Nemania sp. HDF-Br-5, an endophytic fungus of the endangered conifer Pseudotsuga gaussenii Flous

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? 2022 Phytochemical Society of EuropeThree new (psganpenes A-C), one known eremophilane sesquiterpene and one newrelated derivative (psganpene D) were isolated from the culture of endophytic fungus Nemania sp. HDF-Br-5, which derived from Pseudotsuga gaussenii Flous, anendangered conifer endemic to China. Their structures were deduced by extensive spectroscopic methods. All isolates were screened for cytotoxicity and antibacterial activity. Psganpene D showed promising cytotoxicity against KB, HCT116 and Hela cell strains, with IC50 values in the range of 15.1–32.3 μM.

CytotoxicityEremophilane sesquiterpeneNemania sp. HDF-Br-5Pseudotsuga gaussenii Flous

Ding W.、Wang M.、Wan M.、Li J.、Chen H.-W.、Hu J.-F.

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Department of Biological Medicines School of Pharmacy Fudan University

Department of Natural Medicine School of Pharmacy Fudan University

2022

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN:1874-3900
年,卷(期):2022.49
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