首页|Are fungi responsible for the pathogenesis of oral lichen planus?
Are fungi responsible for the pathogenesis of oral lichen planus?
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Introduction: Evolution and modernization have brought into existence new complications of diseases with themself。 One such disease is lichen planus (LP), which is considered a chronic mucocutaneous disorder as well as a psychosomatic disorder affecting the oral and genital mucous membranes, nails, skin and scalp。 Oral lichen planus (OLP) is the mucosal counterpart of cutaneous LP and is characterized by heterogeneous clinical manifestations ranging from mild reticular pattern to severe erosive form。 Although LP shows a strong association with psychological stress, the exact etiology is still unknown。 Nonetheless, the literature strongly supports pathogenesis based on T cell-mediated autoimmunity。 Predisposing or aggravating factors such as mechanical trauma, contact allergens in dental restorative materials or toothpastes, drugs, viral infections, bacterial infections, fungal infections or unidentified agents, may instigate the expression of the LP antigen。