首页|Protein O-mannosylation across kingdoms and related diseases: From glycobiology to glycopathology
Protein O-mannosylation across kingdoms and related diseases: From glycobiology to glycopathology
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NSTL
The post-translational glycosylation of proteins by O-linked α-mannose is conserved from bacteria to humans。 Due to advances in high-throughput mass spectrometry-based approaches， a variety of glycoproteins are identified to be O-mannosylated。 Various proteins with O-mannosylation are involved in biological processes， providing essential necessity for proper growth and development。 In this review， we summarize the process and regulation of O-mannosylation。 The multi-step O-mannosylation procedures are quite dynamic and complex， especially when considering the structural and functional inspection of the involved enzymes。 The widely studied O-mannosylated proteins in human include α-Dystroglycan (α-DG)， cadherins， protocadherins， and plexin， and their aberrant O-mannosylation are associated with many diseases。 In addition， O-mannosylation also contributes to diverse functions in lower eukaryotes and prokaryotes。 Finally， we present the relationship between O-mannosylation and gut microbiota (GM)， and elucidate that O-mannosylation in microbiome is of great importance in the dynamic balance of GM。 Our study provides an overview of the processes of O-mannosylation in mammalian cells and other organisms， and also associated regulated enzymes and biological functions， which could contribute to the understanding of newly discovered O-mannosylated glycoproteins。
O- mannosylationMannosyltransferaseEnzyme structureER-associated protein degradationGut microbiota
Jinpeng Wang、Jing Hang、Minzhen Lu、Yuchuan Xue、Jie Qiao、Lin Tao
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Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third
NSTL
