首页|Thermal analysis applied to the development of nanostructured lipid carriers loading propranolol using quality-by-design strategies
Thermal analysis applied to the development of nanostructured lipid carriers loading propranolol using quality-by-design strategies
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NSTL
Elsevier
This work aimed to employ thermal analysis to develop nanostructured lipid carriers (NLC) using propranolol (PPL) as a model drug. The rationale for this is such delivery system could enable PPL repositioning for the treatment of skin diseases. For this, preformulation studies were first performed following a simplex centroid mixture design using thermal and spectroscopic analytical tools. Next, PPL-loaded NLC were developed, varying the production parameters according to a Box-Behnken design. A high degree of thermal interaction was observed among the formulation components, mainly between the Rosa rubiginosa essential oil and soy lecithin lipids, which resulted in an NLC entrapment efficiency above 98%. Infrared data, in turn, showed the components of the formulation are chemically compatible, even under heating production conditions. The optimized model for PPL-loaded NLC production allowed to accurately control the parameters of particle size and PdI ondemand over a wide range of particle sizes (400-1,500 nm). Particularly, Turrax rotation and Turrax agitation time were the most decisive process parameters for these responses. The optimized model was tested in the production of 500-nm and 900-nm NLC, leading to particle sizes of 569.4 +/- 87.3 nm and 823.9 +/- 58.0 nm, respectively, within the 95% confidence interval. Moreover, the PdI results were also very close to the prediction. In conclusion, the precise control of PPL-loaded NLC characteristics through the optimized model offers exciting perspectives for modulating the PPL skin permeation profile to meet different therapeutic propositions.
NSTL
Elsevier
