首页|Peanut traces in food: A probabilistic risk assessment based on the French MIRABEL survey

Peanut traces in food: A probabilistic risk assessment based on the French MIRABEL survey

扫码查看
原文链接
  • NSTL
  • Elsevier
The risk of reactions due to the unintentional presence of allergens, such as traces in packaged products, remains difficult to characterize. The aim was to assess the risk regarding unintended traces of peanut in packaged food products in peanut allergic patients using original data from the MIRABEL survey. We developed an integrated Bayesian probabilistic risk model based on relevant data including consumption of a panel of selected products with and without precautionary labelling by peanut allergic patients, and their individual threshold dose at oral food challenge (OFC). 785 patients (<16 years: 86%) were included in the survey. Data on OFC and food consumption were available for 238 and 443 patients, respectively. For eight food categories with precautionary labelling (30%) or without (70%), the risk was nil (no peanut traces). For chocolate tablets and spreads, the risk was not significantly different from zero. For appetizers, from the different models and including uncertainty intervals, the mean estimated risk was between 38 reactions for 1 000 000 eating occasions and 55 reactions for 10 000 eating occasions. For the 1% lowest dose reactors at OFC, the estimated risk was between 8 reactions for 10 000 and 71 reactions for 1000 eating occasions. According to these results, the allergic risk related to peanut traces in packaged food products was only significant for the most sensitive allergic consumers of appetizers. If the link between food consumption and threshold dose is not taken into account, individual variability could be overlooked, and the risk underestimated. These findings need to be confirmed by larger and representative studies including non-packaged products.

Accidental allergic reactionPeanut allergyPrecautionary labellingUndeclared allergenBayesian model

Crepet, A.、Just, J.、Papadopoulos, A.、Deschildre, A.

展开 >

French Agcy Food, ANSES, Environm & Occupat Hlth & Safety, Risk Assessment Dept,Methodol & Studies Unit, 27-31 Ave Gen Leclerc, F-94701 Maisons Alfort, France

Grp Hosp Trousseau La Roche Guyon, Allergol Dept, INSERM, Epidemiol Allerg & Resp Dis,IPLESP, F-75001 Paris, France

Univ Lille, CHU Lille,Hop Jeanne Flandre, CIIL,Hop Jeanne Flandre,Ctr Infect & Immun Lille, Unit Pneumol & Allergol Pediat,U1019,UMR 8204, F-59000 Lille, France

2022

10.1016/j.foodcont.2021.108403

Food Control

Food Control

SCI
ISSN：0956-7135
年,卷(期)：2022.131
  • 1
  • 33