首页|Organocatalytic enantioselective electrophilic amination of benzoyl butyrolactones

Organocatalytic enantioselective electrophilic amination of benzoyl butyrolactones

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  • NSTL
  • Elsevier
Organocatalytic electrophilic amination of benzoyl butyrolactones with azodicarboxylates was demonstrated to highly efficiently prepare quaternary carbon stereocenter-bearing alpha-amino-gamma-butyrolactones, key framework in numerous bioactive compounds. The squaramide C3 realized the highest yield (99%) and enantioselectivity (93%).(c) 2022 Elsevier Ltd. All rights reserved.

Asymmetric synthesisOrganocatalysisSquaramideElectrophilic aminationBenzoyl butyrolactoneALPHA-AMINATION13-DICARBONYL COMPOUNDSSYNTHETIC APPROACHALDOL REACTIONCATALYSTSESTERSRECOGNITIONSKELETON

Xu, Yan-Li、Wang, Yu-Xia、Wen, Gen-Fa、Da, Chao-Shan

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Lanzhou Univ

2022

10.1016/j.tetlet.2022.153745

Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
年,卷(期)：2022.95
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