首页|Naked-eye sensing and target-guiding treatment of bacterial infection using pH-tunable multicolor luminescent lanthanide-based hydrogel
Naked-eye sensing and target-guiding treatment of bacterial infection using pH-tunable multicolor luminescent lanthanide-based hydrogel
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NSTL
Elsevier
? 2021 Elsevier Inc.In this work, a pH-tunable multicolor luminescent lanthanide-based hydrogel (CS/DEX/CP) was prepared based on lanthanide coordination polymer (CP), dextran aldehyde (DEX) and chitosan (CS). The CP was obtained by the self-assembly of guanosine acid (GMP), ciprofloxacin (CIP), Eu3+, and Tb3+. As-prepared CS/DEX/CP hydrogel could emit blue, green, and red luminescence of CIP, Tb3+, and Eu3+, respectively. It was also found that the luminescence of CS/DEX/CP hydrogel exhibited visual color change in the pH range of 5.5 to 8. Such pH-sensitive hydrogel was multicolor-responsive to protons produced by bacterial growth, therefore, it could provide early warning of bacterial infection by naked-eye. In addition, the increased acidity resulted in not only the degradation of acid-labile Schiff base linkages between DEX and CS, but also the fracture of coordination between CIP and lanthanide ions. As a result, the released CIP and CS showed significantly antibacterial activity against both S. aureus and E. coli.
Ou K.、Wang Q.、Liao Y.、Yang Y.、Dong X.、Wang H.、Zhou Q.、Zhang B.、Zhang X.
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Key Laboratory of Materials Chemistry for Energy Conversion and Storage of the Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology
Key Laboratory of Rare Mineral Exploration and Utilization Ministry of Land and Resources Geological Experimental Testing Center of Hubei Province
NSTL
Elsevier
