首页|Bioactive constituents from the leaves of Croton tiglium

Bioactive constituents from the leaves of Croton tiglium

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  • NSTL
  • Elsevier
? 2022Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and α-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 μg/mL, while the sesquiterpenoids 11 and 15 showed noticeable α-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 μM, respectively.

Croton tigliumLarvicidal activityPhorbol estersSesquiterpenoidsα-glucosidase inhibitory activity

Jiang Z.-Y.、Liu C.-J.、Li X.-F.、Li Y.、Zuo A.-X.、He H.-P.、Duan L.-K.、Feng J.-E.、Huang C.-Q.、Shi S.-L.

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School of Ethnic Medicine Yunnan University of Chinese Medicine

Key Laboratory of Chemistry in Ethnic Medicinal Resources State Ethnic Affairs Commission & Ministry of Education Yunnan Minzu University

Yunnan Phytopharmaceutical Co. Ltd.

School of Chemical Biology & Environment Yuxi Normal University

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2022

10.1016/j.phytol.2022.03.003

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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