首页|N,O-bidentate ligands-based salicylic spiroborates: A bright frontier of bioimaging
N,O-bidentate ligands-based salicylic spiroborates: A bright frontier of bioimaging
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NSTL
Elsevier
A new series of salicylic spiroborate complexes (SSBs) based on N,O-bidentate 2-(tert-cycloalkylamino)-5-(3-(arylamino)acryloyl)thiophene-3-carbonitriles (NO-SSBs) was obtained and characterized. The optical properties of these compounds were studied and compared with those of analogous BF2-based complexes. The geometries and electronic structures of the NO-SSBs in the ground and excited states, especially their key N-B-O link, were revealed using quantum chemical calculations and compared with the experimental data and photophysical characteristics. Hydrolytic dissociation and photodissociation were considered, and the effects of the NO-SSB structure and nature of the solvent on these reactions were established. Biological investigations elucidated the NO-SSBs ability to penetrate living and fixed cells and selectively accumulate in the endoplasmic reticulum (ER) and Golgi complex. Comparison of the NO-SSBs' characteristics with those of a commercial dye demon-strated the superiority of their properties and prospects for application in the bio-visualization of the ER and Golgi complex.
NSTL
Elsevier
