Are the functions of milk exosomes restricted to their protein cargoes?

Elrashdy M. Redwan Vladimir N. Uversky

Are the functions of milk exosomes restricted to their protein cargoes?

Elrashdy M. Redwan 1Vladimir N. Uversky
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作者信息

  • 1. Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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Abstract

Numerous studies have analyzed the benefits of camel milk health over human and bovine milk. These health benefits range from broad antimicrobial and antiviral potentials to anti-cancer activity and capability to act as anti-diabetics. The milk ingredients behind these benefits are variable and can be changed depending on the lactation season. To explore which components are responsible for these benefits, reports are often focused on the analysis of various biological macro-molecules, but most studies are concentrated on the milk proteome analysis, whereas many other important biomolecules that can be found in milk, such as RNA, polysaccharides, and/or lipids, are mostly ignored in such proteome-centric studies. Noticeable variations are also observed between different studies, with outputs showing strong dependence on the evaluation methods used. Furthermore, recent studies become increasingly focused on the analysis of extracellular vesicles (EVs), such as milk fat globules (MFGs) and/or exosomes, rather than at the entire set of milk constituents. A recently published article by El-kattawy et al. represents an example of such a protein-centric study, where the authors ascribed the in vitro anti-cancer effects of the exosomes extracted from camel milk to the lactoferrin and κ-casein proteins.

Key words

Milk/Extracellular vesicles/Exosomes/Protein/Lipid/Oleic acid

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出版年

2022
Biomedicine & pharmacotherapy

Biomedicine & pharmacotherapy

SCI
ISSN:0753-3322
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