首页|Effect of mass transfer and diffusion on temperature distribution during magnetic hyperthermia
Effect of mass transfer and diffusion on temperature distribution during magnetic hyperthermia
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NSTL
Elsevier
In magnetic hyperthermia (MH), malignant cells are destroyed by heating the tumor tissue. The magnetic nanoparticles (MNs) are injected to tumor region and an alternating magnetic field is exerted to the region. The temperature distribution relates to the MNs distribution inside the tumor. Here, we consider that a spherical tumor tissue is embedded in a normal tissue. We employ a theoretical model to study the distribution of temperature within a tumor with considering injection of MNs inside the tumor. For this goal, the mass transfer and diffusion theories in interstitial tissue are used with Rosensweig's and Pennes equations. We have first obtained analytically.the interstitial pressure and interstitial transfer of MNs by diffusion equation. We have also obtained analytically the concentration distribution inside the tumor. Finally, temperature distribution is obtained numerically. From the obtained results, it is found that the temperature distribution depends on particle size, injection concentration and injection dose. Since the spherical tumor is considered in this work, the injection of magnetic fluid is selected in the radial direction. It is found that the best results for hyperthermia can be obtained with considering the intermediate radius of MNs, high injection dose and concentrations.
NSTL
Elsevier
