首页|GABA mediates NO/cGMP/GSK-3-induced isoflavone accumulation in soybean sprouts
GABA mediates NO/cGMP/GSK-3-induced isoflavone accumulation in soybean sprouts
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NSTL
Elsevier
The effects of glycogen synthase kinase-3 (GSK-3) on nitric oxide (NO)/guanosine 3',5'-cyclic monophosphate (cGMP)-activated gamma-aminobutiric acid (GABA) accumulation and the role of GABA in isoflavone biosynthesis in response to UV-B exposure in soybean sprouts were investigated. The sprouts were sprayed using donors and inhibitors of cGMP and NO as well as inhibitors of GSK-3 and GABA. It turned out that GSK-3, as a second messenger, mediated NO/cGMP/PKG-induced GABA accumulation by activating diamine oxidase (DAO) under UV-B treatment. GABA mediated NO/cGMP/PKG/GSK-3-stimulated the increment of gene and protein expression and activity of chalcone synthase (CHS) and isoflavone synthase (IFS), and consequently induced the elevation in isoflavone content. Overall, GABA mediates NO/cGMP/PKG/GSK-3-stimulated isoflavone production in response to UV-B exposure in soybean sprouts.
UV-B exposureNO/cGMPGSK-3GABAIsoflavone
Jiao, Caifeng、Liu, Yongsheng
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Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
Anhui Agr Univ, Sch Hort, Hefei 230036, Anhui, Peoples R China
NSTL
Elsevier
