首页|Novel biohybrid spongy scaffolds for fabrication of suturable intraoral graft substitutes
Novel biohybrid spongy scaffolds for fabrication of suturable intraoral graft substitutes
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NSTL
Elsevier
? 2022 Elsevier B.V.Despite the fact that classic autograft is the gold standard material for periodontal plastic surgery, it has some drawbacks, including the need for a second surgical site and the scarcity of palatal donor tissues. However, only a few research works on the manufacturing of bioengineered intraoral connective tissue grafts have been conducted. In this work, porous bovine serum albumin methacryloyl/gelatin methacryloyl (BG) biohybrid scaffolds were developed for super-elasticity, shape recovery, suturability for persistent stability, sufficient scaffolding function, and convenient manipulating characteristics to fabricate an intraoral graft substitute with superb stability to resist frequent dynamic forces caused by functional movement (speaking, masticating, and swallowing). Furthermore, in a 3D cell culture assay, BG scaffolds demonstrated excellent cell adhesion and proliferation of L929 cells. In addition, the BG scaffolds were able to release Ibuprofen in a controlled manner for postoperative recovery. The use of a low-cost, optimized cryogelation technique for functional biomacromolecules offers up new possibilities to develop promising scaffolds for dental clinical settings.
Albumin methacryloylCryogelGelatin methacryloylIntraoral graft substituteTissue engineering
Mehwish N.、Lee B.H.、Deng H.、Zaeem M.、Wang Y.、Chen Y.
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Wenzhou Institute University of Chinese Academy of Sciences
Department of Periodontics School & Hospital of Stomatology Wenzhou Medical University
School of Pharmaceutical Sciences Wenzhou Medical University
Department of Orthodontics School & Hospital of Stomatology Wenzhou Medical University
NSTL
Elsevier
