SYNTHESIS AND α-GLUCOSIDASE INHIBITORY ACTIVITY OF URSOLIC ACID,LUPEOL,AND BETULINIC ACID DERIVATIVES

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外文摘要：Seven synthetic derivatives of ursolic acid,lupeol,and betulinic acid(la-lb,2a-2b,and 3a-3c)were synthesized to study their a-glucosidase inhibitory activity.Three of them(2b,3b,and 3c)are new compounds.Among the synthetic derivatives,betulinic acid analogues 3b and 3c exhibited the best activity against a-glucosidase and is superior to the positive agent,with IC_(50)values of 35.0 ± 3,37 and 34.0 ± 1.24 |iM,respectively,

外文关键词：

pentacyclic triterpenoidssynthesisoxone oxidationα-glucosidase inhibition

作者：

Ngoc-Hong Nguyen、Due Dung Pham、Thi-Thanh-Van Le

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作者单位：

CirTech Institute,Ho Chi Minh City University of Technology(HUTECH),475 A Dien Bien Phu Street,Binh Thanh District,Ho Chi Minh City,700000,Vietnam

Department of Chemistry,Ho Chi Minh City University of Education,280 An Duong Vuong Street,Districts,Ho Chi Minh City 748342,Vietnam

出版年：

2021

Химия природных соединений

ISSN：0023-1150

年,卷(期)：2021.(6)