首页|Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
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NSTL
Wiley
Abstract Submicron‐sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear‐resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high‐ and low‐density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high‐density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high‐resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies.
foreign body reactions (response)implant retrievaltotal joint replacementtribologywear debris
Ashley A. Stratton‐Powell、Sophie Williams、Joanne L. Tipper、Anthony C. Redmond、Claire L. Brockett
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Institute of Medical and Biological Engineering, School of Mechanical Engineering,University of
NIHR Leeds Biomedical Research Centre,Leeds Teaching Hospitals NHS Trust
NSTL
Wiley
