首页|Galunisertib-Loaded Gelatin Methacryloyl Hydrogel Microneedle Patch for Cardiac Repair after Myocardial Infarction

Galunisertib-Loaded Gelatin Methacryloyl Hydrogel Microneedle Patch for Cardiac Repair after Myocardial Infarction

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Uncontrolled and excessive fibrosis after myocardial infarction(MI) in the peri-infarct zone leads to left ventricular remodeling and deterioration of cardiac function.Inhibiting fibroblast activation during the mature phase of cardiac repair improves cardiac remodeling and function after MI.Here,we engineered a biocompatible microneedle(MN) patch using gelatin methacryloyl and loaded it with galunisertib,a transforming growth factor-beta(TGF-/i)-specific inhibitor,to treat excessive cardiac fibrosis after MI.The MN patch could sustainably release galunisertib for more than 2 weeks and provide mechanical support for the fragile ventricular wall.After being applied to a rat model of MI,the galunisertib-loaded MN patch improved long-term cardiac function and reduced cardiac fibrosis by effectively inhibiting TGF-β depending on fibroblast activation.This strategy shows the potential of the MN patch as an advanced platform to locally deliver direct antifibrotic drugs to prevent myocardial fibrosis for the treatment of Ml and the promotion of cardiac repair.

myocardial infarctionheart failurecardiac fibrosismicroneedle patchgalunisertib

Haiting Chen、Lu Fan、Ningxin Peng

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Department of Cardiology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing 210008,China

State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering Southeast University,Nanjing 210096,China

Department oj Cardiology,Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University,Nanjing 210008,China

2022

10.1021/acsami.2c05352

ACS applied materials & interfaces

ACS applied materials & interfaces

SCI
ISSN：1944-8244
年,卷(期)：2022.14(36)
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