首页| Radiolytic degradation of levonorgestrel and gestodene: Performance and bioassays

Radiolytic degradation of levonorgestrel and gestodene: Performance and bioassays

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This study reports the feasibility of ionizing sources (~(60)Co source and electron beam radiation) to degrade the progestins hormones levonorgestrel (LNG) and gestodene (GES) in synthetic solutions and real pharmaceutical wastewater (RPW). Doses of 0.5-100 kGy and dose rates of 2.5 and 10 kGy h~(-1) were applied. LNG was shown to be more recalcitrant than GES, with 90% removals achieved at doses around 7.7 kGy (LNG) and 1.6 kGy (GES) in model systems, with LNG showing greater reactivity with reducing species in γ-radiolyis, unlike GES. Furthermore, LNG removal remained around 60% in RPW at low doses, while more than 60% GES removal was observed for all doses. LNG and GES toxicities to Daphnia similis were absorbed dose-dependent, with low doses resulting in toxicity reductions of around 32% (LNG) and 42% (GES); in turn, high doses promoted a fourfold increase in toxicity, y-radiolysis reduced the cytotoxic character of LNG to NIH-3T3-L1 cells, while non-irradiated or irradiated GES solutions did not exhibit any cytotoxic effect. Finally, the estrogenic activity, evaluated by the YES assay, was dose-dependent for both progestins, which may be related to the evolution of transformation products formed by water radiolysis in each case, decreasing for high doses.

ProgestinsPharmaceutical wastewaterGamma-raysElectron beamWater radiolysis

Juliana Mendonca Silva de Jesus、Flavio Kiyoshi Tominaga、Allan dos Santos Argolo

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Research Croup in Advanced Oxidation Processes (AdOx), Department of Chemical Engineering, University of Sao Paulo, Av. Prof, Luciano Cualberto, 380, CEP 05508-010 Sao Paulo, SP, Brazil

Nuclear and Energy Research Institute-IPEN-CNEN/SP, Sao Paulo, Brazil, Av. Prof. Lineu Prestes, 2242, CEP 05508-000 Sao Paulo, SP, Brazil

Rio de Janeiro State University, Department of Sanitary and Environmental Engineering, Rua Sao Francisco Xavier, 524, CEP 20550-900 Rio de Janeiro, RJ, Brazil

2022

10.1016/j.psep.2022.04.021

Transactions of The Institution of Chemical Engineers

Transactions of The Institution of Chemical Engineers

ISSN：0957-5820
年,卷(期)：2022.162
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