Design, synthesis and biological evaluation of difluoroalkylated protoilludanes obtained by a practical radical cascade difluoroalkylation-cyclization reaction
Fang J. Huang H. Yang T. An M. Liu Y. Yang Y. Zhou J. Cao T. Ren Q.
Design, synthesis and biological evaluation of difluoroalkylated protoilludanes obtained by a practical radical cascade difluoroalkylation-cyclization reaction
Fang J. 1Huang H. 1Yang T. 2An M. 2Liu Y. 2Yang Y. 2Zhou J. 3Cao T. 3Ren Q.3
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作者信息
1. Xiangya School of Nursing Central South University
2. Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science & Engineering
3. Sichuan Chenyu Forestry Development Limited Liability Company
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Abstract
? 2021 Elsevier LtdA radical cascade difluoroalkylation-cyclization of β-Caryophyllene with iododifluoromethyl ketones provides a practical method for the synthesis of difluoroalkylated protoilludanes in excellent yield. Further, these fluorinated compounds displayed interesting biological activities against human ovarian cancer cells (A2780 and SKOV-3) and lung cancer cells (A549) showcasing the value of this modification strategy.
NSTL
Elsevier