首页|PREPARATION,STRUCTURE ELUCIDATION,AND CYTOTOXIC ACTIVITY OF AMIDE DERIVATIVES OF HYDROXYSYDONIC ACID
PREPARATION,STRUCTURE ELUCIDATION,AND CYTOTOXIC ACTIVITY OF AMIDE DERIVATIVES OF HYDROXYSYDONIC ACID
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NSTL
Hydroxysydonic acid(1),a naturally abundant bisabolane sesquiterpenoid metabolite,has been obtained from the endophytic fungus Aspergillus versicolor isolated from Elaeocarpus decipiens Hemsl.To increase its pharmacological potential,seven new amide derivatives la-lg were semisynthesized and elucidated.All of the compounds were evaluated for their cytotoxic and antifouling activities.Compound la was found to show cytotoxic activity against gastric carcinoma cell line(HGC-27)with an IC_(50)value of 9.72 μg/mL.
Hubei Key Laboratory of Natural Product Research and Development(China Three Gorges University),College of Biological and Pharmaceutical Sciences,China Three Gorges University,443002,Yichang,P.R.China
NSTL
