Facile synthesis of delta-ketoesters via formal two-carbon insertion into beta-ketoesters
Jiang, Yan 1Xi, Song 1Wang, Qi 1Fu, Lin 2He, Ling 1Wang, Zhen 1Zhang, Min1
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作者信息
1. Chongqing Univ
2. Cent Nervous Syst Drug Key Lab Sichuan Prov
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Abstract
A formal two-carbon insertion into b-ketoesters with vinylmetal has been developed for the rapid syn-thesis of d-ketoesters. This method features high efficiency, simple operation, and mild conditions with-out the usage of bases and catalysts. The reaction is postulated to proceed via a tandem process involving nucleophilic addition of vinylmetal to ketone, retro-aldol reaction to give an enolate anion and an enone, and finally Michael addition of these two intermediates. (c) 2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier