首页|The endocrine role of bone: Novel functions of bone-derived cytokines

The endocrine role of bone: Novel functions of bone-derived cytokines

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  • NSTL
  • Elsevier
Bone-derived cytokines refer to various proteins and peptides that are released from the skeleton and can distribute in organisms to regulate homeostasis by targeting many organs, such as the pancreas, brain, testicles, and kidneys. In addition to providing support and movement, many studies have disclosed the novel endocrine function of bone, and bone can modulate glucose and energy metabolism as well as phosphate metabolism by versatile bone-derived cytokines. However, this specific exoskeleton function of bone-derived cytokines in the regulation of homeostasis and the pathological response caused by skeletal dysfunction are still not very clear, and elucidation of the above mechanisms is of great significance for understanding the pathological processes of metabolic disorders and in the search for novel therapeutic measures for maintaining organ stability and physical fitness.

Bone-derived cytokineEndocrine functionExoskeletal regulationHomeostasis

Wang, Hui、Zheng, Xuanqi、Zhang, Yan、Huang, Jinfeng、Zhou, Wenxian、Li, Xunlin、Tian, Haijun、Wang, Bin、Xing, Dan、Fu, Weili、Chen, Tao、Wang, Xiangyang、Zhang, Xiaolei、Wu, Aimin

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Wenzhou Med Univ, Dept Orthopaed, Zhejiang Prov Key Lab Orthopaed, Affiliated Hosp 2, Wenzhou

Xi An Jiao Tong Univ, Ctr Translat Med, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China

Shanghai Jiao Tong Univ, Shanghai Key Lab Orthopaed Implants, Dept Orthopaed Surg, Shanghai Ninth

Nanjing Univ, Sch Med, Dept Sports Med & Adult Reconstruct Surg, Nanjing Drum Tower Hosp,Affiliated

Peking Univ, Arthrit Clin & Res Ctr, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China

Sichuan Univ, Dept Orthopaed, West China Hosp, Chengdu, Peoples R China

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2021

10.1016/j.bcp.2020.114308

Biochemical Pharmacology

Biochemical Pharmacology

ISTP
ISSN：0006-2952
年,卷(期)：2021.183
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