Phytochemistry2022，Vol.19910.DOI:10.1016/j.phytochem.2022.113209

Corybungines A?K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

Han Y. Hou T. Zhou H. Wang J.-X. Feng J.-T. Liu Y.-F. Guo Z.-M. Liang X.-M. Zhang Z.-H. Zhu Y.-H. Cheng J.-X.
Phytochemistry2022，Vol.19910.DOI:10.1016/j.phytochem.2022.113209
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  • NSTL
  • Elsevier

Corybungines A?K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

Han Y. 1Hou T. 1Zhou H. 1Wang J.-X. 1Feng J.-T. 1Liu Y.-F. 1Guo Z.-M. 1Liang X.-M. 1Zhang Z.-H. 2Zhu Y.-H. 3Cheng J.-X.4
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作者信息

  • 1. Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences
  • 2. School of Biological Engineering Dalian Polytechnic University
  • 3. Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine Ganjiang Chinese Medicine Innovation Center
  • 4. DICP-CMC Innovation Institute of Medicine
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Abstract

? 2022 Elsevier LtdEleven undescribed isoquinoline alkaloids corybungines A?K including a protoberberine-type alkaloid, an isoquinoline alkaloid with a unique 6-norprotoberberine skeleton, one 13,14-seco-protoberberine-type alkaloid, two 1a,14-seco-protoberberine-type alkaloids with a 4-(hydroxymethyl)phenoxy moiety and six aporphine alkaloids, together with seven known alkaloids, have been isolated from the whole herb extract of Corydalis bungeana Turcz. Their structures and absolute configurations were elucidated based on an analysis of spectroscopic data and electronic circular dichroism (ECD) spectra. (R)-stephanine displayed high antagonistic activity against the dopamine D2 receptor with an IC50 value of 0.85 ± 0.09 μM in CHO-D2 cells. Additionally, corybungines D, F, H, (R)-roemerine, (R)-vireakine and (R)-tuduranine showed moderate D2 antagonism (IC50 5.20–26.07 μM). The preliminary structure-activity relationships (SARs) of aporphine alkaloids were discussed.

Key words

Corybungines A?K/Corydalis bungeana Turcz./D2 antagonistic activity/Isoquinoline alkaloids/Papaveraceae

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量2
参考文献量30
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