首页|Corybungines A?K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

Corybungines A?K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

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  • NSTL
  • Elsevier
? 2022 Elsevier LtdEleven undescribed isoquinoline alkaloids corybungines A?K including a protoberberine-type alkaloid, an isoquinoline alkaloid with a unique 6-norprotoberberine skeleton, one 13,14-seco-protoberberine-type alkaloid, two 1a,14-seco-protoberberine-type alkaloids with a 4-(hydroxymethyl)phenoxy moiety and six aporphine alkaloids, together with seven known alkaloids, have been isolated from the whole herb extract of Corydalis bungeana Turcz. Their structures and absolute configurations were elucidated based on an analysis of spectroscopic data and electronic circular dichroism (ECD) spectra. (R)-stephanine displayed high antagonistic activity against the dopamine D2 receptor with an IC50 value of 0.85 ± 0.09 μM in CHO-D2 cells. Additionally, corybungines D, F, H, (R)-roemerine, (R)-vireakine and (R)-tuduranine showed moderate D2 antagonism (IC50 5.20–26.07 μM). The preliminary structure-activity relationships (SARs) of aporphine alkaloids were discussed.

Corybungines A?KCorydalis bungeana Turcz.D2 antagonistic activityIsoquinoline alkaloidsPapaveraceae

Han Y.、Hou T.、Zhou H.、Wang J.-X.、Feng J.-T.、Liu Y.-F.、Guo Z.-M.、Liang X.-M.、Zhang Z.-H.、Zhu Y.-H.、Cheng J.-X.

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Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences

School of Biological Engineering Dalian Polytechnic University

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine Ganjiang Chinese Medicine Innovation Center

DICP-CMC Innovation Institute of Medicine

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2022

10.1016/j.phytochem.2022.113209

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.199
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