首页|Two new isocoumarins isolated from a mangrove-derived Penicillium sp.

Two new isocoumarins isolated from a mangrove-derived Penicillium sp.

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  • NSTL
  • Elsevier
? 2022Two new isocoumarins named peniciisocoumarins I and J (1?2), together with four known analogues (3?6), were obtained from Penicillium sp. GXIMD 03001, an endophytic fungus derived from the rhizophoraceous mangrove Kandelia candel. The structures and absolute configurations of 1 and 2 were determined by detailed analysis of their NMR, MS spectroscopic data, a modified Mosher's method and electronic circular dichroism data. All isolated isocoumarins were evaluated for their cytotoxic activity against four human cancer cell lines (SPCA-1, BEL-7402, GSC-7901 and MCF-7). However, none of the compounds exhibited any appreciable activity (IC50 > 50 μM).

Cytotoxic activityIsocoumarinsKandelia candelMangrovePenicillium sp

Gan Y.-M.、Zhao L.-Y.、Liu K.、Tang Z.-Z.、Huang B.-Y.、Liu Y.-H.、Gao C.-H.、Bai M.、Xia J.-L.

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Institute of Marine Drugs Guangxi University of Chinese Medicine Nanning

2022

10.1016/j.phytol.2022.04.011

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.50
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