首页|Sympathetic vasomotor outflow during low‐intensity leg cycling in healthy older males

Sympathetic vasomotor outflow during low‐intensity leg cycling in healthy older males

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  • NSTL
  • Wiley
New Findings What is the central question of this study? Sympathetic vasomotor outflow is reduced during low‐intensity dynamic leg exercise in younger individuals: does ageing influence the sympathoinhibitory effect during low‐intensity leg cycling? What is the main finding and its importance? Muscle sympathetic nerve activity during low‐intensity cycling decreased in older males, as seen in young males. It is possible that cardiopulmonary baroreflex‐mediated inhibition of sympathetic vasomotor outflow during dynamic leg exercise is preserved in healthy older males. Abstract Muscle sympathetic nerve activity (MSNA) is reduced during low‐intensity dynamic leg exercise in young males. It is suggested that this inhibition is mediated by loading of the cardiopulmonary baroreceptors. The purpose of this study was to clarify the impact of age on MSNA during dynamic leg exercise. Nine younger males (YM, mean?±?SD, 20?±?1?years) and nine older males (OM, 72?±?3?years) completed the study. The subjects performed two 4‐min cycling exercises at 10% of their heart rate reserve using a cycle ergometer in a semirecumbent position (MSNA and estimated central venous pressure (eCVP) trials). MSNA was recorded via microneurography of the left radial nerve. The CVP was estimated based on peripheral venous pressure, which was monitored using a cannula in the right large antecubital vein. The magnitude of the increase in mean arterial blood pressure during leg cycling was larger in OM (+9.3?±?5.5?mmHg) compared with YM (+2.8?±?4.7?mmHg). MSNA burst frequency was decreased during cycling in both YM (–8.1?±?3.8?bursts/min) and OM (–10.6?±?3.3?bursts/min), but no significant difference was found between the two groups. The eCVP increased during exercise in both groups, and there was no difference in the changes in eCVP between YM (+1.1?±?0.4?mmHg) and OM (+1.2?±?0.7?mmHg). These data indicate that inhibition of sympathetic vasomotor outflow during low‐intensity cycling appears in OM as seen in YM. It is possible that the muscle pump‐induced loading of the cardiopulmonary baroreflex is preserved during cycling in healthy older males.

ageingblood pressuredynamic exerciseMSNAsympathetic nerve activity

Keisho Katayama、Mitsuru Saito、Koji Ishida、Kaori Shimizu、Kana Shiozawa、Sahiro Mizuno、Shigehiko Ogoh

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Research Center of Health,Nagoya University

Applied Physiology Laboratory,Toyota Technological Institute

Faculty of Human Development,Kokugakuin University

Graduate School of Medicine,Nagoya University

Research and Development,Hosei University

Department of Biomedical Engineering,Toyo University

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2022

10.1113/EP090497

Experimental physiology.

Experimental physiology.

ISSN：0958-0670
年,卷(期)：2022.107(8)
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