Tetrahedron letters2022，Vol.924.DOI:10.1016/j.tetlet.2022.153679

A rare sesquiterpenoid-alkaloid hydrid with selective BuChE tory activity from Valeriana officinalis var. latifolia Miqinhibi

Wang, Miaomiao Wang, Shuliang Li, Yanan Wu, Panfeng Yi, Ping Huang, Liejun Gu, Wei Zhou, Chengyan Yuan, Chunmao Hao, Xiaojiang
Tetrahedron letters2022，Vol.924.DOI:10.1016/j.tetlet.2022.153679
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  • NSTL
  • Elsevier

A rare sesquiterpenoid-alkaloid hydrid with selective BuChE tory activity from Valeriana officinalis var. latifolia Miqinhibi

Wang, Miaomiao 1Wang, Shuliang 1Li, Yanan 1Wu, Panfeng 1Yi, Ping 1Huang, Liejun 1Gu, Wei 1Zhou, Chengyan 2Yuan, Chunmao 1Hao, Xiaojiang1
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作者信息

  • 1. Guizhou Med Univ
  • 2. Hebei Univ
  • 折叠

Abstract

Valerianofal A (2), a rare sesquiterpenoid-alkaloid hydrid, as well as two biosynthetic related compounds (1 and 3) was isolated from the roots of Valeriana officinalis var. latifolia Miq. Compound 2 represented the first germacrane-type sesquiterpenoid and tecostidine hydrid. Their structures as well as absolute configurations were elucidated by spectroscopic analysis, an alkaline hydrolysis method, and X-ray diffraction. The structure of volvalerenic acid A was revised by single-crystal X-ray diffraction. Compounds 2 and 3 displayed selective BuChE inhibitory activities with IC50 values ranging from 0.4 mu g/ml to 2.8 mu g/ml. The possible recognition mechanism between compound 2 and BuChE was predicted by molecular docking analysis. (C) 2022 Elsevier Ltd. All rights reserved.

Key words

Valeriana officinalis var. latifolia Miq/Rare Sesquiterpenoid-alkaloid hydrid/Volvalerenic acid A/Structure revision/BuChE inhibitory activity/ROOTS

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量1
参考文献量19
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