Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae

Akone, Sergi Herve ¹Wang, Hao ²Mouelle, Eitel Ngoh Misse ³Mandi, Attila ⁴Kurtan, Tibor ⁴Koliye, Pierre Roger ³Hartmann, Rudolf ⁵Bhatia, Sanil ⁶Yang, Jing ⁶Muller, Werner E. G. ⁷Lai, Daowan ⁸Liu, Zhen ¹Kalscheuer, Rainer ¹Proksch, Peter¹

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作者信息

1. Heinrich Heine Univ
2. Chinese Acad Trop Agr Sci
3. Univ Douala
4. Univ Debrecen
5. Forschungszentrum Julich
6. Heinrich Heine Univ Duesseldorf
7. Univ Med Johannes Gutenberg Univt Mainz
8. China Agr Univ
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Abstract

Chemical investigation of the fungal endophyte Pseudopestalotiopsis theae isolated from leaves of Caloncoba welwitschii, collected in Cameroon, resulted in two previously undescribed sulfur-containing xanthone derivatives sydoxanthones D and E, in addition to three previously undescribed monomeric diisoprenyl-cyclohexene-type meroterpenoids biscognienynes D-F and five known natural products. The structures of the undescribed compounds were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis. Mosher's reaction was performed to determine the absolute configuration of sydoxanthones D and E while TDDFT-ECD calculations were used to assign the configuration of biscognienyne D. Biscognienynes B and D showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with IC50 values of 7.7 and 6.7 mu M and against the human leukemic cell lines HL60, and Hal-01 with IC50 values ranging from 4.3 to 12.1 mu M.

Key words

Pseudopestalotiopsis theae/Amphisphaeriaceae/Endophytic fungus/Sulfur-containing xanthone/Meroterpenoids/Cytotoxicity/FUNGUS TRUNCATELLA-ANGUSTATA/ENDOPHYTIC FUNGUS/ISOPRENYLATED CYCLOHEXANOLS/DERIVATIVES/CHEMISTRY/ACID

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出版年

2022

Phytochemistry

CCR

ISSN：0031-9422

被引量2

参考文献量34

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