首页|Anti-diabetic activity of Vaccinium bracteatum Thunb. leaves' polysaccharide in STZ-induced diabetic mice

Anti-diabetic activity of Vaccinium bracteatum Thunb. leaves' polysaccharide in STZ-induced diabetic mice

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  • NSTL
  • Elsevier
Vaccinium bracteatum Thunb. (VBT) is a traditional Chinese herbal medicine. The anti-diabetic activity of VBT leaves' polysaccharide (VBTLP) is studied in this paper. The results indicated VBTLP had a dose-dependent decrease on the blood glucose (BG) level, and the time effect of VBTLP on BG level was also significant. The insulin level of high dose group (HDG) was significantly higher (p<. 0.05) than that of model control (MC) group. Compared to MC, HDG and lose dose group (LDG) had significantly lower (p<. 0.05) TC and LDL-C levels, however, TG and HDL-C levels are similar. Compared to non-diabetic control (NC), HDG and LDG had similar plasma lipid levels except for higher LDL-C level. Although body weights of LDG and HDG were significant lower (p<. 0.05) than that of NC from week 2 to week 6, they were similar to that of PC. The results indicate VBTLP possesses a potential hypoglycemic effect in streptozotocin-induced diabetic mice.

Anti-diabetic activityPolysaccharidesVaccinium Bracteatum Thunb

Xu, M.、Wang, Y.、Cheng, S.、Liebrecht, A.、Zhang, Y.、Qian, H.、Zhang, H.、Qi, X.、Wang, L.

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Department of Mathematics, Illinois State University, IL, Normal, 61761, United States

Academy of State Administration of Grain, Beijing, 100037, China

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Jiangsu, Wuxi, 214122, China

China National Research Institute of Food and Fermentation Industries, Beijing, 100027, China

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2013

10.1016/j.ijbiomac.2013.07.028

International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

EISCI
ISSN：0141-8130
年,卷(期)：2013.61
  • 44
  • 34