首页|Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy

Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy

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We have designed and synthesized a family of Ir(III) metal complexes coordinated with two cyclometalated bis-fluorophenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir (dipy)-l), an a-chloroacetyl ester (Ir(dipy)-2) or a chain containing an ammonium cation (Ir(dipy)-3). The Ir (III) complexes feature a high triplet state population enabling red phosphorescence and efficient singlet oxygen generation. Ir(dipy)-2 and Ir(dipy)-3 are demonstrated to stain cells in both one-photon and two-photon confocal imaging. Moreover, Ir(dipy)-2 and Ir(dipy)-3 produce ROS in cells upon irradiation, inducing cell death by apoptosis. Colocalization studies in SK-Mel-103 cells show that Ir(dipy)-3 is partially accumulated in mitochondria and induces upon irradiation a disruption in their morphology. Overall our studies demonstrate that the prepared Ir(III) act as photosensitizers able to kill cells under irradiation, being suitable candidates for photodynamic therapy applications.

DipyrromethenesIridium(III) complexesPhotosensitizersSinglet oxygenPhotodynamic therapy

A. Prieto-Castaneda、A. Lerida-Viso、E. Avellanal-Zaballa

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Depdrtamento de Quimica Orgdnica, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain

Unidad Mixta de Investigation en Nanomedicina y Sensores, IIS La Fe, Universitat Politecnica de Valencia, Avda de Fernando Abril Martorel1 nl06, 46026, Valencia, Spain

Departamento de Quimica Fisica, Universidad del Pais Vasco-EHU, Apartado 644, 48080, Bilbao, Spain

2022

10.1016/j.dyepig.2021.109886

Dyes and Pigments

Dyes and Pigments

EISCI
ISSN：0143-7208
年,卷(期)：2022.197
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