首页|New cyclopeptide alkaloid of Condalia buxifolia and the absolute stereochemistry of Condaline A
New cyclopeptide alkaloid of Condalia buxifolia and the absolute stereochemistry of Condaline A
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
During the course of a study of Condalia buxifolia (Rhamnaceae), one new cyclopeptide alkaloid condaline B (1), together with six known cyclopeptide alkaloids, condaline A (2), and the scutianines B (3), - D (4) and -E (5), frangulanine (6), and 3,4,28-tris-epi-scutianene N (7), were isolated from the rind bark of Condalia buxifolia. Their structures have been confirmed through spectroscopic analyses such as 1D and 2D NMR experiments. The absolute stereochemistry of condaline A (2), was elucidated by X-ray crystal structure determination of its HI salt. In addition, condaline B (1) was obtained synthetically through a structural transformation of condaline A. Meanwhile, the crude methanol extract, the basic ether fraction, and alkaloids 1-7 were tested against various strains of Gram-positive and Gram-negative bacteria and fungus, showing promising antimicrobial activity
Gehm, Adriana Z.、Cunha, Sabrina B.、Silva, Bruce W. da、Mostardeiro, Marco A.、Bastos, Nelci. R.、Burrow, Robert A.、Caro, Miguel S. B.、Dalcol, Ionara I.、Morel, Ademir F.
NSTL
Elsevier
