首页|A REVIEW ON THE ROLE OF QUINONES IN CARDIOVASCULAR DISEASE VIA INHIBITING NLRP3 INFLAMMASOME
A REVIEW ON THE ROLE OF QUINONES IN CARDIOVASCULAR DISEASE VIA INHIBITING NLRP3 INFLAMMASOME
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NSTL
Polskie Towarzystwo Farmaceutyczne
Cardiovascular disease has caused huge health and economic burden all over the world. NLRP3 inflammasome-induced inflammatory cascade leading to pyroptosis is one of the hot spots in the pathogenesis of cardiovascular disease. Therefore, it is very important to inhibit the activity of NLRP3 inflammasome and search for natural active compounds for the prevention and treatment of cardiovascular disease. Quinones have good myocardial protection, and their function is closely related to anti-inflammatory and anti-oxidation. 9 natural quinones for the treatment of cardiovascular disease based on the inhibition of NLRP3 inflammasome were summarized and screened. Docking results showed cryptotanshinone had a better binding activity with NLRP3, which can provide theoretical support for finding novel NLRP3 inflammasome inhibitors or lead compounds in the future.
NSTL
Polskie Towarzystwo Farmaceutyczne
