Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153592

Synthesis of salicylates from anionically activated aromatic trifluoromethyl group

Xie H. Lin C. Wang R. Liu J.-B.
Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153592
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  • NSTL
  • Elsevier

Synthesis of salicylates from anionically activated aromatic trifluoromethyl group

Xie H. 1Lin C. 1Wang R. 1Liu J.-B.1
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作者信息

  • 1. Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and Technology
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Abstract

? 2021 Elsevier LtdAn efficient approach to salicylates via a novel transformation of anionically activated aromatic trifluoromethyl group is described. Anionically activated trifluoromethyl group can react with phenols/alcohols under alkaline conditions to afford aryl/alkyl salicylates in high yields. Mechanism studies indicate that the carbonyl oxygen atom of ester is from the H2O in the solvent.

Key words

2-(Trifluoromethyl)-phenol/C–F bond activation/Nucleophile/Salicylate/Trifluoromethyl group

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量24
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