首页|Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum

Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropePhytochemical research on an extract of Notopterygium incisum yielded twenty-four compounds (1–24), including four new compounds 7, 10, 13 and 17. The structures of new compounds were elucidated by spectroscopic analysis, and the absolute configuration of 5 were assigned via Mosher's method. In addition, compounds 2, 9, 19 and 24 were analyzed by single crystal X-ray analysis for the first time. The new compound 7 exhibited remarkable cytotoxic activity against the human pancreatic cancer cell lines PANC-1, CAPAN-2, CFPAC-1, and SW1990 with IC50 values of 6.25 ± 0.54, 7.74 ± 1.12, 6.68 ± 1.11, and 5.35 ± 0.33 μM, respectively. The primary mechanistic study indicated that 7 caused cell death probably due to induced defects in the mitotic process. Moreover, compounds 2 and 7-9 effectively protected against H2O2-induced neurotoxicity in the SH-SY5Y cells, and 1, 3, 6, 10, 11, 16 and 19 exhibited strong DPPH scavenging ability.

Chemical constituentsCytotoxicityNeuroprotective effectNotopterygium incisumUmbelliferae

Ma L.-M.、Chai T.、Wang C.-B.、Ma L.、Meng X.-H.、Wang K.、Wang W.-F.、Sang C.-Y.、Yang J.-L.、Zheng Y.-D.、Farimani M.M.

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CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences (CAS)

College of Life Science Northwest Normal University

Department of Phytochemistry Medicinal Plants and Drugs Research Institute Shahid Beheshti University

2022

10.1016/j.phytol.2022.03.007

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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