首页|Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity

Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity

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  • NSTL
  • Elsevier
? 2022Tabernaemontana corymbosa is a traditional folk medicine. In our research, six monoterpene indole N-oxide alkaloids and their parent alkaloids were obtained from the stem bark of T. corymbosa, including seven new alkaloids (1–7) and five known alkaloids (8–12). Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, and DP4+ probability analyses. The antimicrobial activity of the obtained compounds was evaluated, among which alkaloids 4, 8, 12 showed significant antimicrobial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL, while alkaloids 11, 12 showed moderate antimicrobial activity against Bacillus subtilis with an MIC value of 25 μg/mL.

Antimicrobial activityIndole alkaloidsStructural elucidationTabernaemontana corymbosa

Fan K.、Gao W.、Ding C.-F.、Deng S.-Y.、Tan B.-Y.、Wu H.、Song J.-F.、Zhang L.-C.、Zhang R.-P.、Yu H.-F.、Guo Y.

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School of Pharmaceutical Science Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University

School of Basic Medical Sciences Kunming Medical University

2022

10.1016/j.fitote.2022.105178

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.158
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