Fitoterapia2022，Vol.1587.DOI:10.1016/j.fitote.2022.105178

Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity

Fan K. Gao W. Ding C.-F. Deng S.-Y. Tan B.-Y. Wu H. Song J.-F. Zhang L.-C. Zhang R.-P. Yu H.-F. Guo Y.
Fitoterapia2022，Vol.1587.DOI:10.1016/j.fitote.2022.105178
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  • NSTL
  • Elsevier

Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity

Fan K. 1Gao W. 1Ding C.-F. 1Deng S.-Y. 1Tan B.-Y. 1Wu H. 1Song J.-F. 1Zhang L.-C. 1Zhang R.-P. 1Yu H.-F. 1Guo Y.2
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作者信息

  • 1. School of Pharmaceutical Science Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University
  • 2. School of Basic Medical Sciences Kunming Medical University
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Abstract

© 2022Tabernaemontana corymbosa is a traditional folk medicine. In our research, six monoterpene indole N-oxide alkaloids and their parent alkaloids were obtained from the stem bark of T. corymbosa, including seven new alkaloids (1–7) and five known alkaloids (8–12). Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, and DP4+ probability analyses. The antimicrobial activity of the obtained compounds was evaluated, among which alkaloids 4, 8, 12 showed significant antimicrobial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL, while alkaloids 11, 12 showed moderate antimicrobial activity against Bacillus subtilis with an MIC value of 25 μg/mL.

Key words

Antimicrobial activity/Indole alkaloids/Structural elucidation/Tabernaemontana corymbosa

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量3
参考文献量31
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