首页|Biosensors for Caspase-3: From chemical methodologies to biomedical applications

Biosensors for Caspase-3: From chemical methodologies to biomedical applications

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  • NSTL
  • Elsevier
Caspase-3 plays irreplaceable roles in apoptosis and related diseases. An imbalance in the measured levels of Caspase-3 is implicated in irreversible apoptosis. Therefore, the detection of Caspase-3 is of great significance for apoptosis imaging and the evaluation effect of early tumor treatment and other diseases. Herein, advances in the recent innovations of Caspase-3 response fluorescence biosensors, including molecular probes and nanoprobes, are systematically summarized in sections corresponding. The performances of various luminescence probes in Caspase-3 detection are discussed intensively in the design strategy of chemical structure, response mechanism and biological application. Finally, the current challenges and prospects of the design of new Caspase-3 responsive fluorescence probes for apoptosis imaging, or similar molecular event are proposed.

Caspase-3BiosensorsFluorescence imagingBiomedicalMulti-functionalAGGREGATION-INDUCED EMISSIONRESONANCE ENERGY-TRANSFERLIGHT-UP PROBE2-PHOTON FLUORESCENT-PROBESMALL-MOLECULE PROBESSIGNAL TURN-ONCELL APOPTOSISMEMBRANE-PERMEANTSURFACE-CHEMISTRYELECTRON-TRANSFER

Lei, Qian、Huang, Xueyan、Zheng, Lijuan、Zheng, Fan、Dong, Jie、Chen, Fei、Zeng, Wenbin

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Cent South Univ

2022

10.1016/j.talanta.2021.123198

Talanta

Talanta

EISCI
ISSN：0039-9140
年,卷(期)：2022.240
  • 10
  • 174