首页|Three new cassane diterpenoids from the seed kernels of Caesalpinia sinensis

Three new cassane diterpenoids from the seed kernels of Caesalpinia sinensis

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  • NSTL
  • Elsevier
? 2021Three new cassane derivatives, caesall FE (1) and caesalminaxin HC-HD (2-3), together with four known compounds (4-7) were separated from the seed kernels of Caesalpinia sinensis, and their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially 1D and 2D NMR and HRESIMS. Compounds 1-3 represented the new examples of cassane diterpenoids containing an isomerized furan ring fused with an aromatized C ring or conjugated with one additional double bond. Biological evaluation revealed that compounds 1-7 could inhibit the overproduction of NO induced by LPS, and compounds 2 and 4-6 exhibited the inhibitory ration more than 60 % at the concentration of 50 μM.

Anti-inflammatory activityCaesalpinia sinensisCassane diterpenoids

Li P.、Zhang B.-H.、Zhu Z.-W.、Jing W.-H.、Wang M.、Gao H.-Y.

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Department of Pharmaceutical Engineering Shanxi Pharmaceutical Vocational College

School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

2022

10.1016/j.phytol.2021.12.004

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
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